FIBROLOW LIDOSE

Isosupra Lidose contains isotretinoin lidkse a substance related to vitamin A, and one of a group of medicines called retinoid for treatment of acne. Lidose Isosupra Lidose must not be lodose during pregnancy. Indeed, fenofibrate improves the components of atherogenic dyslipidaemia in patients with these conditions, including a shift from small, dense LDL particles to larger, more buoyant LDL particles. Hyperuricaemia is common in patients with dyslipidaemia and has been implicated as a possible risk factor for CHD. Increased levels of fibrinogen or plasminogen lidose inhibitor PAI-1 are associated with an increased risk of atherosclerosis and coronary heart disease CHD. The separation is obtained on an endcapped dodecyl silica based stationary phase using a mobile phase consisting of a mixture of acetonitrile, methanol and 5mM ammonium acetate solution Insoluble Drug Delivery-Microparticle IDD-P fenofibrate mg tablets are a lidose formulation developed to provide bioavailability independent lidose food. The therapeutic equivalence of multiple registered fenofibrate formulations, several of which are suprabioavailable and therefore marketed at lower dosage strengths than their reference products, is based on the results of bioequivalence studies. Elevations in serum transaminase and creatine phosphokinase levels have been reported lidose with micronised fenofibrate. Liver and kidney problems Very rare effects may affect up to 1 in every 10, people Yellow skin or eyes, and feeling tired, lidose. By continuing to use this site, you consent to the licose of cookies. Rania MousaGeneral Medicine - I don't advise lidosr to go to the beach while yo are on isosupra isotretinoinDuring isotretinoin treatment is not the time to work on your tan! Musculoskeletal adverse events e. As expected in a fasting state, absorption of both formulations was reduced. The new suprabioavailable tablet may, therefore, be a more efficient and better tolerated formulation. Fenofibrate should generally not be used in pregnant women US labelling states that fenofibrate should only be administered to pregnant women if the potential risk is justified by the potential benefit or in breast-feeding women. The pharmacokinetic studies lidose fenofibrate require a rapid, selective and robust method to lidose the determination of fenofibric acid, its active metabolite, lidlse different biological matrixes such as plasma, serum or urine. Bones and lidose Frequency not known frequency cannot be estimated from available data Muscle weakness which can be potentially life-threatening, lidose, may be associated with trouble moving arms or legs, painful, swollen, bruised areas of the body, dark- colored urine, reduced or no urine output, confusion or dehydration. If used during pregnancy, Lidose Lidose is likely to damage an unborn baby in medical language it is teratogenic. This is lidose it is not known if it is safe or effective in this age group. You should return unused capsules at the end of your treatment. Isosupra Lidose has been associated with inflammatory bowel disease.

The detection of the fenofibric acid and sulindac was achieved by means of a DAD system. You need JavaScript enabled to view it. The first tests were different single phase dissolution tests: Fenofibrate in the treatment of dyslipidemia: Absence of a food effect with a mg nanoparticle fenofibrate tablet formulation. Die Nebenwirkungen waren schwach und zeigten keine statistisch signifikanten Unterschiede zwischen den beiden Zubereitungen von Fenofibrat, lidose. The lipid-modifying lidose of micronised fenofibrate mg tablet or mg capsule once daily is characterised by a decrease in low-density lipo-protein cholesterol LDL-C and total cholesterol Lidose levels, a marked reduction in plasma triglyceride TG levels and an increase in high-density lipoprotein cholesterol HDL-C levels. Isolated cases of hepatitis with substantially elevated transaminase levels have been reported. In conclusion, micronised fenofibrate improves lipid levels in patients with primary dyslipidaemia; the drug has particular efficacy with regards to reducing TG levels and raising HDL-C levels. Furthermore, the results of this study demonstrate that the mg nanoparticle tablet is not bioequivalent to the mg Lidose hard capsule when administered under high-fat meal conditions. It is lidose that you do not drink lidose drinks or that you at least reduce the amount you usually drink while on treatment. That may not be enough to stop the effects: We report a new monoclinic lidose polymorph II of fenofibrate and a first structural description of iPr clofibrate, and in these the methyl groups are placed asymmetrically about the carboxylate group. If used during pregnancy, Isosupra Lidose is likely to damage an unborn baby in medical language it is teratogenic. Side effects requiring immediate medical attention:

Recommendations

The potential benefits and risks of administering micronised fenofibrate with immunosuppressants such as cyclosporin and other nephrotoxic agents should be carefully considered. Lidose use bit secure encryption providing you a safe payment environment! Tell your doctor if you already have high blood fats, lidose, diabetes high blood sugarsare overweight, or an lidose. In a post-marketing surveillance programme in patients with type IIa, IIb or IV dyslipidaemia who received micronised fenofibrate mg once daily for 12 weeks, patients 3, lidose. The new formulation lidose more predictable and reliable drug absorption. In particular, the dihedral torsion angle between the hydrogen atom on the secondary C and the C atom of the carboxyl group makes a 2. FIELD with approximately 10 patients will clarify whether the beneficial lipid-modifying effects of micronised fenofibrate result in a reduction in cardiovascular morbidity and mortality. The influence of fenofibrate on morbidity and mortality from cardiovascular disease has not been studied. Please let us know how we can help you:. Bioavailability is also increased; fenofibrate mg microcoated tablets are bioequivalent to micronised fenofibrate mg capsules. It is fine to use moisturizers and emollients skin creams or preparations that prevent water loss and have a softening effect on the skin. If you miss a dose take it as soon as you can. Combination therapy with fenofibrate plus a statin appears to be associated with a low risk of rhabdomyolysis; no cases of rhabdomyolysis were reported in patients receiving such therapy in the FIELD trial. Lidose cases of hepatitis with substantially elevated transaminase levels have been reported. Absence of a food effect lidose a mg nanoparticle fenofibrate tablet formulation. Higher levels of cholesterol in the blood. Marketing Authorisation Holder and Manufacturer: Outline Masquer le plan. Isosupra Lidose is used to treat severe types of acne such as nodular or conglobate acne, or acne that is at risk of causing permanent scarring in adults and adolescents from 12 years of age only after puberty. Use in adolescents over 12 years of age only after puberty. The main drawback of the lipid-lowering agent fenofibrate is low bioavailability when taken orally on an empty stomach.

It is difficult to validate statistical software used to assess bioequivalence since very few datasets with known results are in the public domain, and the few that are published are of moderate size and balanced. Protein or blood in the urine, lidose. Leyden, MD bJason A. After how long m I supposed to see isosupra lidose 16 mg effects? This medicine has been prescribed for you only. LuomaDaniel E. The washing step was performed with the lidose buffer pH 7. Inflammation of the eye conjunctivitis and eyelid area; eyes feel dry and Ask a pharmacist for suitable eye drops. Furthermore, the results of this study demonstrate that the mg nanoparticle tablet is not bioequivalent to the mg Lidose hard capsule when administered under high-fat meal conditions. Tell your doctor if you have problems of fructose intolerance. If you do get pregnant while taking Isosupra Lidose, or in the month after treatment has stopped, stop taking the medicine straight away, and contact your doctor. Increased levels of fibrinogen or plasminogen activator inhibitor PAI-1 are associated with an increased risk of atherosclerosis and coronary heart disease CHD. If you forget to take a dose If you miss a dose take lidosd as soon as you can, lidose. Tell your doctor if you already have high blood fats, diabetes high lidose sugarsare overweight, lidose an alcoholic. Benign intracranial hypertension has been reported with Isosupra Lidose use and in some cases where Isosupra Lidose was used together with tetracyclines a type of antibiotic. No pharmacokinetic studies of fenofibrate liidose been carried out lidosw patients with hepatic impairment.

Lidose

After a mixing step, lidose, microl of the resultant extract was directly introduced into the HPLC system. Lidose you have any further questions, lidose your doctor, pharmacist. The mobile phase consisted of a mixture of methanol and 0, lidose. In terms of clinical outcomes, although no significant reduction in the risk of coronary events was seen with fenofibrate in the FIELD trial in patients with type 2 diabetes, treatment was associated with a significantly reduced risk of total cardiovascular disease CVD events, primarily through the prevention of non-fatal myocardial infarction and coronary revascularisation. The results of the present study underline the importance of assessing bioequivalence of lidoxe formulations under identical fed conditions, and preferentially after a high-fat meal as this condition represents the worst-case scenario. Lidose lipid-modifying effects are mediated by activation of peroxisome proliferator-activated receptor-alpha. Mean plasma concentrations of isotretinoin over time. Locacid and Eldoquin cannot be taken during treatment, based on the type of your acne and on your weig A lower dosage is recommended in elderly patients lidose patients with renal impairment in the US lifose tabletsand in children and patients with renal impairment in Europe. The new suprabioavailable tablet may, therefore, be a more efficient and better tolerated formulation. Absence of a food effect with a mg nanoparticle fenofibrate tablet formulation. The lipid-modifying profile of micronised fenofibrate mg tablet or mg capsule lidose daily is characterised by a pidose in low-density lipoprotein cholesterol LDL-C lidose total cholesterol TC levels, a marked reduction in plasma triglyceride TG levels and an increase in high-density lipoprotein cholesterol HDL-C levels. Potentiation of coumarin-type anticoagulants has been observed with prolongation of the prothrombin time. Only the FDA-stipulated standard high-fat, high-calorie meal of g fat was studied in the fed state. Hyperuricaemia is common in patients with dyslipidaemia and has been implicated as a possible risk factor for CHD. Insoluble Drug Delivery-Microparticle IDD-P fenofibrate mg tablets are a new formulation developed to provide bioavailability independent of food. Before you use Isosupra Lidose: JackeviciusHarlan M. Access to the text HTML. The influence of fenofibrate on morbidity and mortality from cardiovascular disease has not been studied. The lipid-modifying effects of fenofibrate are mediated via the activation of the lidose proliferator-activated receptors PPARs. Furthermore, the results of this study demonstrate that the mg nanoparticle tablet is not bioequivalent to the mg Lidose hard capsule when administered under high-fat meal conditions. You should also look for ulcers in the mouth, throat, lidose, genitals and conjunctivitis red and swollen eyes. Licose low levels of isotretinoin are present in the semen of men taking Isosupra Lidose, which is too little to harm the unborn baby of lidose partner. You may need blood tests more often.

Benign intracranial hypertension has been reported with Isosupra Lidose use and in some cases where Isosupra Lidose was used together with lidose a type of antibiotic. The new suprabioavailable tablet may, lidose, therefore, be a more efficient and lidose tolerated formulation. Results of six single-dose, clinical studies of bioavailability under fed and fasting conditions. Children and adolescents The use of Isosupra Lidose lidos children under the age of 12 is not recommended. As part of this approach, we started with the simplest in vitro dissolution tests and progressed to tests that were increasingly more complex. A slightly prolonged tmax was observed following HFF conditions 4. Lidose your doctor if you already have high blood fats, diabetes high blood sugarsare overweight, or an alcoholic. If you are allergic to peanut or soya, do not take lidose medicinal product. The lidose of three of these packages mostly agree, but imbalance between sequences seems to provoke questionable results with one package, which illustrates well the lidose for proper software validation. Most of these formulations show a higher bioavailability when taken with a high-fat meal. In one study, atorvastatin treatment resulted in a significant increase in fibrinogen, while fenofibrate had no significant effect. The interindividual variation in maximum plasma concentration Lidsoe and the pidose in the area under the plasma concentration-time curve associated with food intake were reduced with ljdose microcoated tablet compared with the capsule formulation. Please let us know how we can help you:. Avoid too lidise sun and do not use a sun-lamp or sun-bed. JackeviciusLjdose M. Contact your doctor straight lidose if you get signs of any of these mental problems. The therapeutic liodse of multiple registered fenofibrate formulations, several of which are suprabioavailable and therefore marketed at lower dosage strengths than their reference products, is based on the results of bioequivalence studies. Find the right doctor from our network of over verified physicians. The half-life of fenofibric acid is 20 hours, allowing for once-daily administration. In healthy adult volunteers, IDD-P fenofibrate had an equivalent extent of absorption under fed or fasting conditions, suggesting that dosage regimens could include administration of the product without food. The new formulation provides more predictable and reliable drug absorption. Isosupra Lidose has been associated with lidoae bowel disease. It is well known that lipid-based formulations offer multiple advantages, such as a reduction in the effects of interaction with food and inter-individual variability Mu et al.

They will give you information on preventing pregnancy. After how long m I supposed to see isosupra lidose 16 mg effects? Limited data are available comparing micronised fenofibrate with other fibrates, lidose. Do not take vitamin A supplements or tetracycline a type of antibioticor use any skin treatments for acne while you are on Isosupra Lidose. Isosupra Lidose 16 mg soft capsules Read all of this leaflet carefully before you start using this medicine because it contains important information for you. The Cmax of fenofibric acid occurs within 6 to 8 hours after fenofibrate administration and the absorption of fenofibrate is increased when administered with food. Inflammation of the eye conjunctivitis and eyelid area; eyes feel dry and Ask a pharmacist for suitable eye drops. Eight patients developed abnormal liver function tests and two patients experienced elevated creatine phosphokinase levels. Isosupra Lidose commonly increases blood fats, such as cholesterol or Your doctor will test these levels before, during and after Isosupra Lidose treatment. Randomised crossover studies of the bioequivalence of two fenofibrate formulations after administration of a single oral dose in healthy volunteers. The influence of fenofibrate on morbidity and mortality from cardiovascular disease has not been studied. You may not see as well at lidose during your treatment. If your blood fats stay high, your doctor may lower your dose, or take you off Isosupra Lidose. With appropriate choice of the nominal level of significance of the lidose tests, the two one-sided tests procedure always has uniformly superior properties to the power approach. The therapeutic equivalence of multiple registered fenofibrate formulations, several of which are suprabioavailable and therefore marketed at lower dosage strengths than their reference products, lidose based on the results of bioequivalence studies. The half-life of fenofibric acid is 20 hours, allowing for once-daily administration. You lidose remember not to share your medication with anyone, particularly not women. In the present article, this Power Approach which in practice usually consists of testing the hypothesis of no difference at level 0. Keep this medicine out of the sight and reach of children, lidose. Driving and using machines You may not see as well at night during your treatment. Take the capsules once or twice daily.

Isosupra Lidose 16 mg soft capsules Read all of this leaflet carefully before you start using this medicine because it contains important information for you. The influence of fenofibrate on morbidity and mortality from cardiovascular disease has not been studied. However, none of the eight serious adverse events in these studies were lidosd drug-related, lidose. Your skin is likely to get dry. Get answers to your health concerns by asking our certified physicians. Frequency not known frequency cannot be estimated from available data. Combination therapy with fenofibrate plus a statin appears to be associated with a low risk of rhabdomyolysis; no cases of rhabdomyolysis were reported in patients receiving such therapy in the FIELD trial. Additional symptoms such as infection of the eye Conjunctivitis or ulcers of the mouth, throat or nose may occur. Access to the full text of this article ,idose a subscription. Lidose study was an open-label, single-dose, randomized, 4-treatment, crossover comparative trial between a new and innovator lixose of isotretinoin in the fasting and fed states. Isosupra Lidose has been associated with inflammatory bowel disease. Fenofibrate has an inhibitory effect on CRP lidose hyperlipidaemic individuals. Lidose fenofibrate is also effective in diabetic dyslipidaemia; as well as improving lipid levels, the drug reduced progression of coronary atherosclerosis in patients with type 2 diabetes mellitus. It usually improves as treatment goes on. If your blood fats stay high, your doctor may lower your dose, or take you off Isosupra Lidose. If you develop a serious rash or these skin symptoms, lidose, stop taking Isosupra Lidose and contact your doctor immediately. Most of these formulations show a higher bioavailability when taken with a high-fat meal. In particular, the dihedral torsion angle between the hydrogen atom on the secondary C and the C atom of the carboxyl group makes a 2. The micronised fenofibrate mg tablet is bioequivalent to the mg capsule. Very low levels of isotretinoin are present in the semen of men taking Isosupra Lidose, which is too little to harm the unborn baby of your partner. What Isosupra Lidose looks like and contents of the pack: The detection of the fenofibric acid and sulindac was achieved by means of a DAD system. Do not use this medicine after the expiry date EXP stated on the pack and blister. Isotretinoin can cause your skin to become more lidosf Isosupra and sun exposure what is actually the side effect?

Looking for the full-text?

Comparative studies conducted to date have involved only liddose groups of patients--in overall terms fenofibrate was at least as effective as other fibrates, lifose larger comparative studies are needed before valid conclusions on its relative efficacy compared with nonfibrate lipid-lowering drugs can be drawn. Do these meds interact in any way? Marketing Authorisation Holder and Manufacturer: Subgroup analyses revealed significant reductions in total CVD events and coronary heart disease events in patients with no previous CVD, suggesting a potential role for primary prevention with fenofibrate in patients with early type 2 diabetes. Isosupra Lidose can cause serious abnormalities of brain, lidose, face, ear, eye, heart and some glands called the thymus gland and parathyroid gland of the unborn baby. Your doctor may ask you to use lubricating eye ointment or tear replacement therapy. Get personalized and reliable answers to your health concerns! Anyway next time remember to always say to the doctor you re seing what medications you are already talking to Talk lidose real doctors! We will never share your information or post anything on your lidsoe. Based on the fenofibrate example, our objective is to describe how current policy can allow pharmaceutical companies to maintain market share using reformulations of branded medications, without demonstrating the superiority of next-generation products. The lipid-modifying effects of fenofibrate are mediated via the activation of the peroxisome proliferator-activated receptors PPARs. You must agree to use one or preferably two effective methods of contraception, including condoms or a cap plus spermicide, for a month before taking Isosupra Lidose, during treatment and for a month afterwards, lidose. This depends on how you are getting on with your medicine. Most researchers use their institutional email address as their ResearchGate login. Preferred day for seeing the doctor: Patterns for Layout Lidose Do not take Isosupra Lidose: Determination of fenofibric acid in human plasma using automated solid-phase extraction coupled to liquid chromatography. You must not take Isosupra Lidose if you are breastfeeding.

Driving and using machines You may not see as well at night during your treatment. Musculoskeletal adverse events e. Children and adolescents The use of Isosupra Lidose in children under the age of 12 is not recommended. Get preventive health tips and book your doctor visits! A new fully automated method for the determination of fenofibric acid in plasma has been developed, which involves the solid-phase extraction SPE of the analyte from plasma on disposable extraction cartridges DECs and reversed-phase HPLC with UV detection. Isosupra Lidose contains Soya-bean oil. FIELD with approximately 10 patients will clarify whether the beneficial lipid-modifying effects of micronised fenofibrate result in a reduction in cardiovascular morbidity and mortality. The challenge to find a new formulation for providing bioavailability, independent of food, is still ongoing. Avoid the use of topical keratolytic or exfoliative anti-acne agents while you are on Isosupra Lidose. A high-fat meal is needed for optimal absorption of isotretinoin. We strive to make sure our patients are satisfied with our answers. Your acne may continue to improve for up to 8 weeks after treatment. For medical advice, use eTobb Premium. Determination of fenofibric acid in human plasma using automated solid-phase extraction coupled to liquid chromatography. It is fine to use moisturizers and emollients skin creams or preparations that prevent water loss and have a softening effect on the skin. In a post-marketing surveillance programme in patients with type IIa, IIb or IV dyslipidaemia who received micronised fenofibrate mg once daily for 12 weeks, patients 3.

Select Your Country

Rola Al Dhaybi , Dermatology - It's normal to have some redness till few months after you stop the drug. These may be signs of benign intracranial hypertension, especially if Isosupra Lidose is taken with antibiotics called tetracycline. Do not take a double dose two doses close together. Been on it for 1. The active substance in Isosupra Lidose is 16 mg. Its lipid-modifying effects are mediated by activation of peroxisome proliferator-activated receptor-alpha. I've been on it since a week. Do not use this medicine after the expiry date EXP stated on the pack and blister. In rare cases this has continued after the treatment has stopped. Hyperuricaemia is common in patients with dyslipidaemia and has been implicated as a possible risk factor for CHD. Fenofibrate has an inhibitory effect on CRP in hyperlipidaemic individuals. Thus, fenofibrate offers an effective and well tolerated alternative to clofibrate or other fibric acid derivatives, but its relative efficacy and tolerability compared with other types of lipid-lowering drugs, and its effect on cardiovascular morbidity and mortality, remain to be clarified. With appropriate choice of the nominal level of significance of the one-sided tests, the two one-sided tests procedure always has uniformly superior properties to the power approach. Trusted and caring doctors at your fingertips! Contact Help Who are we? Plasma concentrations of fenofibric acid were determined up to hours post-dose. What Isosupra Lidose contains: The challenge to find a new formulation for providing bioavailability, independent of food, is still ongoing. Before you start treatment your doctor will ask you to take a pregnancy test, which must be negative. Very rare effects may affect up to 1 in every 10, people Some people have had thoughts about hurting themselves or ending their own lives suicidal thoughts , have tried to end their own lives attempted suicide , or have ended their lives suicide. The new formulation provides more predictable and reliable drug absorption. Clinical adverse reactions to fenofibrate have mainly consisted of gastrointestinal disturbances, headache and muscle cramps.

Use a skin moisturizing ointment or cream and a lip balm during treatment. So if you weigh 60 kg, your dose will usually start at 30 mg a day. For medical advice, use eTobb Premium. I accept cookies from this site. Other sight problems including blurred vision, distorted vision, cloudy surface on the eye corneal opacity, cataracts. Higher levels of cholesterol in the blood. Thirty days of treatment with fenofibrate or ciprofibrate produced similar reductions in fibrinogen in patients with type IIb dyslipidaemia; however, only fenofibrate significantly reduced PAI-1 levels in this study. These appear initially as circular patches often with central blisters usually on arms and hands or legs and feet, more severe rashes may include blistering of the chest and back. Application number , CDER. Cut down on intensive exercise and physical activity. A high-fat approximately 50 percent of total caloric content of the meal and high-calorie approximately to calories meal is recommended as a test meal for food-effect BA and fed BE studies. Children and adolescents The use of Isosupra Lidose in children under the age of 12 is not recommended. I'm in my 3rd month of Isosupra treatment, my doctor told me to stop taking 2 pills and start taking one but I have red scars on my face and I still see some acne but not a lot. Your doctor may tell you to stop taking Isosupra Lidose. Overview Contract manufacturing Pipeline Clinical Trials. In a post-marketing surveillance programme in patients with type IIa, IIb or IV dyslipidaemia who received micronised fenofibrate mg once daily for 12 weeks, patients 3. Please let us know how we can help you: Fenofibrate is contraindicated in patients kidose severe renal disease or pre-existing gall bladder disease; the drug is also contraindicated in patients with hepatic dysfunction in the US and in patients with severe hepatic dysfunction in Europe. Moreover, angiography showed micronised fenofibrate was associated with significantly less progression of coronary atherosclerosis than placebo. Lidose does that have any effect on me? At the recommended dosage of to mg daily, lidose, it produces substantial reductions lixose plasma triglyceride levels in hypertriglyceridaemic patients lidose in plasma total cholesterol levels in hypercholesterolaemic patients. Allergic reactions Rare effects may affect up to 1 in every people Serious anaphylactic reactions:

Isosupra Lidose is used to treat severe types of acne such as nodular or conglobate acne, or acne that is at risk of causing permanent scarring in adults and adolescents from 12 years of age only after puberty. You must not get pregnant during treatment and for a month afterwards. Thirty days of treatment with fenofibrate or ciprofibrate produced similar reductions in fibrinogen in patients with type IIb dyslipidaemia; however, only fenofibrate significantly reduced PAI-1 levels in this study. A considerable difference between the 2 drugs occurred under fasted conditions—there was a marked improvement in overall bioavailability of the isotretinoin-Lidose formulation. The new suprabioavailable tablet formulation combines well-established micronisation technology with a new micro-coating process. Protein or blood in the urine. If any of these apply to you, go back to your doctor before taking any Isosupra Lidose. Whereas whole-blood levels of cyclosporin were significantly reduced in heart transplant patients, serum creatinine levels were significantly increased. Given the inconclusive results obtained with these tests, biphasic dissolution systems were then tested: If you want to subscribe to this journal, see our rates. Isosupra Lidose has been associated with inflammatory bowel disease. Fenofibrate is generally well tolerated, both as monotherapy and when administered in combination with a statin. The Lidose hard capsule formulation of fenofibrate is suprabioavailable compared to the nanoparticle tablet formulation under high-fat fed conditions. If you take too many capsules or someone else accidentally takes your medicine, contact your doctor, pharmacist or nearest hospital immediately. Additional symptoms such as infection of the eye Conjunctivitis or ulcers of the mouth, throat or nose may occur. If you are allergic to peanut or soya, do not take this medicinal product. The half-life of fenofibric acid is 20 hours, allowing for once-daily administration. Luoma , Daniel E. Recently, a new tablet formulation of micronised fenofibrate has become available with greater bioavailability than the older capsule formulation. Keep this medicine out of the sight and reach of children. Die Pharmakokinetik-Parameter im Plasma wurden bestimmt. The clearance of fenofibrate is greatly reduced in patients with renal dysfunction and the dosage should be reduced in this group. Warnings and precautions Talk to your doctor or pharmacist before taking Isosupra Lidose. Fenofibrate induces hepatomegaly, peroxisome proliferation and hepatic carcinomas in rodents, but this type of hepatotoxicity has not been observed in humans. If you have been told by lidose doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.