Sildenafil Dosage

Date of revision of the dkse. Across all trials, the proportion of patients reporting improvement on sildenafil were as follows: Nitric oxide then recommended the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate cGMPproducing smooth muscle relaxation in the corpus cavernosum and reccommended inflow of blood. Example Ddose Sildenafil Prescription: Recmmended healthy male volunteers, sildenafil at steady state 80 mg t. Hypromellose Lactose monohydrate Triacetin Titanium dioxide E 6. Sildenafil has vasodilator properties, resulting in mild and transient decreases in blood pressure see section 5. Back to top Pfizer Limited contact details. Avoiding Side Effects Your doctor writes a 40 mg prescription of generic sildenafil. Your doctor can gradually increase your dose to 60 mg 3 tablets80 mg 4 tabletsor the maximum daily dose of sildenfail— mg 5 tablets. Subscribe to free Drugs. Initiation of sildenafil at a dose of dos mg should be considered see dose 4. There is a fold selectivity over PDE6 which is involved in the phototransduction pathway in the retina, recommended dose of sildenafil. Pharmaceutical form Film-coated tablet. In a specific interaction study, where sildenafil mg was co-administered with amlodipine in hypertensive patients, there was an additional reduction on supine systolic blood pressure of 8 mmHg. Reporting suspected adverse reactions after authorisation of the medicinal product is important. Effects of other medicinal products on sildenafil In vitro sildenafil Concomitant use with alpha-blockers. Mechanism of action Sildenafil is an oral therapy for erectile dysfunction. Refer to our editorial policy for content sources and attributions.

General disorders and administration site conditions. Many events were reported to occur during or shortly after sexual intercourse and a few were reported to occur shortly after the use of Sildenafil without sexual activity. Sildenafil has no effect on visual recommended silsenafil contrast sensitivity. In three specific drug-drug interaction studies, the alpha-blocker doxazosin 4 mg and 8 mg and silddnafil 25 mg, 50 mg, or mg recommennded administered simultaneously to patients with benign prostatic hyperplasia BPH stabilized on doxazosin therapy, recommended dose of sildenafil. Maximum observed plasma concentrations are reached within 30 to minutes median 60 minutes of oral dosing in the fasted state. The biggest difference between Viagra and generic sildenafil is si,denafil amount of active ingredient in each pill. No significant interactions were shown when sildenafil 50 mg was co-administered with tolbutamide mg or warfarin 40 mgboth of which are metabolised by CYP2C9. Blood pressure Patient advice: If priapism is not treated immediately, penile tissue sildenafil and permanent loss sipdenafil potency could result. Paediatric population Sildenafil is not indicated for individuals below 18 years of age. Musculoskeletal and connective tissue disorders. Company contact details Pfizer Limited. In cases of overdose, standard supportive measures should be adopted as required. Sildenafil metabolism is principally mediated by the cytochrome P CYP isoforms 3A4 major route and 2C9 minor route. Concomitant use with alpha-blockers. In the event of an erection that persists longer than 4 hours, the patient should seek immediate medical assistance. The following patient groups were represented: One of the benefits of generic sildenafil over Viagra is that sildenafil comes in smaller 20 mg dose tablets. Measures dose treatment satisfaction and sexual experience significantly favored the mg dose compared with the mg dose in the DBPC. To bookmark a medicine you must recommendrd up and log in.

Active ingredient

Blood pressure Patient advice: Pooling of the following classes of antihypertensive medication: The results demonstrated no clinically sildfnafil differences between sildenafil and placebo in sldenafil to limiting angina. FDA alerts for all medications. Posology Use in adults The recommended dose is 50 mg taken as needed approximately one hour before sexual activity. Clinical efficacy and safety. These decreases in blood pressure are consistent with the vasodilatory effects of sildenafil, probably due to increased cGMP levels in vascular smooth muscle. Consider protective measures against sexually transmitted diseases. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum but potently enhances the relaxant effect of NO on this tissue. The most commonly reported adverse reactions in clinical studies among sildenafil treated patients were headache, flushing, dyspepsia, nasal congestion, dizziness, nausea, hot flush, visual disturbance, cyanopsia and vision blurred. There are no data on the interaction recommended sildenafil and non-specific phosphodiesterase inhibitors such as theophylline or dipyridamole. Dosse of men with erectile dysfunction, which is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance. To email a medicine you must sign up and log in. Prior to prescribing sildenafil, physicians should carefully consider whether their patients with certain underlying conditions could be adversely affected by such vasodilatory effects, especially recommenfed combination recommendrd sexual activity. In addition, physicians should advise patients what to sildenafil in the event of postural hypotensive symptoms. Single oral doses of sildenafil up to mg in healthy sildwnafil produced no clinically relevant effects on ECG. Improvements in DBPC patient-reported outcomes from baseline were statistically significant for both sildenafil 50 and mg compared with placebo. The maximum recommended dosing frequency is once per day.

Not all pack sizes may be marketed. There is a fold selectivity over PDE6 which is involved in the phototransduction pathway in the retina. Stronger CYP3A4 inhibitors such as ketoconazole and itraconazole would be expected to have greater effects. You find that a 20 mg dose 1 tablet gives you the erection you want. Concomitant administration with ritonavir: Although specific interaction studies were not conducted for all medicinal products, population pharmacokinetic analysis showed no effect of concomitant treatment on sildenafil pharmacokinetics when grouped as CYP2C9 inhibitors such as tolbutamide, warfarin, phenytoinCYP2D6 inhibitors such as selective serotonin reuptake inhibitors, recommended dose of sildenafil, tricyclic antidepressantsthiazide and related diuretics, loop and potassium sparing diuretics, angiotensin converting enzyme inhibitors, calcium channel blockers, beta-adrenoreceptor antagonists or inducers of CYP metabolism such as rifampicin, barbiturates. Use in adults The recommended dose is 50 mg taken as needed approximately one hour before sexual activity. When sildenafil dose doxazosin were administered simultaneously to patients stabilized on doxazosin therapy, there were infrequent reports of patients who experienced symptomatic postural hypotension. Renal dialysis is not expected to accelerate clearance as sildenafil is highly dose to plasma proteins and not eliminated in the urine. Sildenafil mg did not affect the steady state recommended of the HIV protease inhibitors, saquinavir and ritonavir, both of which are CYP3A4 substrates. One of the benefits of generic sildenafil over Viagra is that sildenafil comes in smaller 20 mg dose tablets. The co-administration of PDE5 inhibitors, including sildenafil, sildenafil guanylate cyclase stimulators, such as riociguat, is contraindicated as it may potentially lead to symptomatic hypotension see section 4. Sildenafil is an oral therapy for erectile dysfunction. Sildenafil Rating User Reviews 8. Agents sildenafil the treatment of erectile dysfunction, including sildenafil, should not be used in men for whom sexual activity is inadvisable e. Its effect is more potent on PDE5 than on other known phosphodiesterases. Based on these pharmacokinetic results co-administration of sildenafil with ritonavir is not advised see section 4. The most commonly reported adverse reactions in clinical studies among sildenafil treated patients were headache, flushing, dyspepsia, nasal recommended, dizziness, nausea, hot flush, visual disturbance, cyanopsia and vision blurred. Consider protective measures against sexually transmitted diseases. The major circulating metabolite results from N-demethylation of sildenafil.

Recommended dose of sildenafil

Sildenafil is rapidly absorbed. The N-desmethyl metabolite is further metabolised, with a terminal half-life of approximately 4 h. Therefore sexual stimulation is required in order for sildenafil to produce its intended beneficial pharmacological effects. Method of recommended For oral use. As dizziness and altered vision were reported in clinical trials with sildenafil, patients should be aware of how they react to Sildenafil, before driving or operating machinery. This site uses cookies. Name of the medicinal product 2. Measures of treatment satisfaction and sexual experience significantly favored the mg dose compared with the mg dose in the DBPC. Reporting suspected adverse reactions after authorisation of the medicinal product is important. Based on these pharmacokinetic results co-administration of sildenafil with ritonavir is not advised see section 4. The film coating of sildenafil tablet contains lactose. Prolonged dose and priapism have been reported with sildenafil in post-marketing experience. Based on efficacy and tolerability, the dose may be increased to mg or decreased to 25 mg. Pharmaceutical form Film-coated tablet. What is Sildenafil and How Does it Work? The safety of sildenafil has not been studied in the following sub-groups of patients and its use is therefore contraindicated: Microcrystalline cellulose Calcium hydrogen phosphate anhydrous Croscarmellose sodium Magnesium stearate Film coat: Applies to the following strengths: Population pharmacokinetic analysis of clinical trial data indicated a reduction in sildenafil clearance when co-administered with CYP3A4 inhibitors such as ketoconazole, erythromycin, cimetidine.

Enter medicine name or company Dose typing to retrieve search suggestions. Prior to initiating any treatment recommmended erectile dysfunction, physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity. Because not all adverse reactions are reported to the Marketing Authorisation Holder and included in the safety database, the frequencies of recommendec reactions cannot be reliably determined. Has not been studied. Posology Use in adults The recommended dose is 50 mg taken as needed approximately one hour before sexual activity. To email a medicine you must sign up and log in. Consider protective measures against sexually transmitted diseases. One of the benefits dose generic sildenafil over Viagra is that sildenafil comes in smaller 20 mg dose tablets. In a study of healthy male volunteers, co-administration of the endothelin antagonist, bosentan, an inducer of CYP3A4 sildenafil, CYP2C9 and possibly of CYP2C19 at steady state mg twice a day with sildenafil at steady state 80 mg three times a day resulted in These reports included dizziness and light-headedness, but not syncope. These decreases in blood pressure are consistent with the vasodilatory effects of sildenafil, probably due to increased cGMP levels in vascular smooth muscle. The following patient groups were recommended Order before February 11th to get your delivery by Valentine's Day. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum but potently enhances the relaxant effect of NO on this tissue. This site uses cookies. Based on recommended pharmacokinetic results co-administration of sildenafil with ritonavir is not advised see section 4. In the event of an erection that persists longer than 4 hours, the patient should seek immediate sildenafil assistance. The corresponding change in supine diastolic blood pressure was 5. Sildenafil metabolism is principally mediated by the cytochrome P CYP isoforms 3A4 major route and 2C9 minor route. Pharmacokinetics in special patient groups. There was no increase in adverse events with the higher dose. There is no safety information on the administration of sildenafil to patients with bleeding disorders or active sjldenafil ulceration.

Concomitant use with alpha-blockers Caution is advised when sildenafil is administered to patients taking an alpha-blocker, as the sildenafil may lead to symptomatic hypotension in a few susceptible individuals see section 4. Paediatric population Sildenafil is not indicated for individuals below 18 years of age. In a study of dose male volunteers, co-administration of the endothelin antagonist, bosentan, an inducer of CYP3A4 [moderate], CYP2C9 and possibly of CYP2C19 at steady state mg twice a day with sildenafil at steady state 80 mg three times a day resulted in Sildenafil has no effect on visual acuity or contrast sensitivity. Prescribing Generic Sildenafil for ED Generic sildenafil is only approved to treat sildenafil hypertension. Chest pain, Fatigue, Feeling hot. Adding Revatio R to bosentan therapy does not result in any beneficial effect on exercise capacity. The corresponding change recommended supine diastolic blood pressure was 5. Distribution The mean steady state volume of distribution V d for sildenafil is recommended, indicating distribution into the tissues. Increasing Your Dose Your doctor writes a 40 mg prescription of generic sildenafil. There is no safety information on the administration of sildenafil to patients with bleeding disorders or active peptic ulceration. Concomitant administration of sildenafil to patients taking alpha-blocker therapy may lead to symptomatic hypotension in a few susceptible individuals. General dose and administration site conditions. And they can only drop from 50 mg to 25 mg if side effects are a problem. The pharmacokinetics of sildenafil in patients with severely impaired hepatic function have not been studied. Women Sildenafil is not indicated for use by women.

What is Sildenafil and How Does it Work?

We comply with the Recmomended standard for trustworthy health information - verify here. What is Sildenafil and Doxe Does recommended Work? Refer to our editorial policy for content sources and attributions. Its effect is more potent on PDE5 sildenacil on other known phosphodiesterases. Studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro. Caution is advised when sildenafil is administered to patients taking an alpha-blocker, as the co-administration may dose to symptomatic hypotension in a few susceptible individuals see section 4. FDA alerts for all medications. Qualitative decommended quantitative composition Each tablet contains 25 mg, 50 mg or mg of sildenafil as citrate Excipient with known effect: Sildenafil had no effect on saquinavir pharmacokinetics see section 4. Agents for pulmonary hypertension Impotence agents. Continue typing to refine. When sildenafil and doxazosin were administered simultaneously sildenafil patients stabilized on doxazosin therapy, there were infrequent reports of patients who experienced symptomatic postural hypotension. Pooling of the following classes of antihypertensive medication: When a single mg dose sildejafil sildenafil was administered with erythromycin, a moderate CYP3A4 inhibitor, at steady state mg twice daily. The N-desmethyl metabolite is further metabolised, with a terminal half-life of approximately 4 h. In healthy volunteers receiving sildenafil mg single doseless than 0. Sildenafil had no effect on ritonavir pharmacokinetics. Studies in vitro have shown that sildenafil is selective for PDE5, which is involved in the erection process.

Erectile dysfunction medication works by preventing the chemical process that lets blood leave an erect penis. Pharmacodynamic effects Studies in vitro have shown that sildenafil is selective for PDE5, which is involved in the erection process. Protein binding is independent of total drug concentrations. Sildenafil is not indicated for use by women. Concomitant use with alpha-blockers Caution is advised when sildenafil is administered to patients taking an alpha-blocker, as the co-administration may lead to symptomatic hypotension in a few susceptible individuals see section 4. In addition, initiation of sildenafil at a dose of 25 mg should be considered see sections 4. Therefore sildenafil should be administered to these patients only after careful benefit-risk assessment. The corresponding change in supine diastolic blood pressure was 5. Generic Viagra also costs a fraction of what Viagra costs. Because not all adverse reactions are reported to the Marketing Authorisation Holder and included in the safety database, the frequencies of these reactions cannot be reliably determined. This is most likely to occur within 4 hours post sildenafil dosing. Priapism Agents for the treatment of erectile dysfunction, including sildenafil, should be used with caution in patients with anatomical deformation of the penis such as angulation, cavernosal fibrosis or Peyronie's disease , or in patients who have conditions which may predispose them to priapism such as sickle cell anaemia, multiple myeloma or leukaemia. They just come in slightly different doses and Viagra costs more than sildenafil. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Effects on vision Cases of visual defects have been reported spontaneously in connection with the intake of sildenafil and other PDE5 inhibitors see section 4. Nitric oxide then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate cGMP , producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. White to off-white, rounded diamond-shaped tablets, of dimensions

White to off-white, rounded diamond-shaped tablets, of dimensions Reporting suspected adverse reactions after authorisation of the medicinal product is important. Sign Up Log In Cancel. However, due to high inter-subject variability, these differences were not statistically significant. These additional blood pressure reductions were of a similar magnitude to those seen when sildenafil was administered alone to healthy volunteers see section 5. This increase is particularly helpful for dealing with:. By clicking Subscribe, I agree to the Drugs. Women Sildenafil is not indicated for use by women. Pharmacodynamic effects Studies in vitro have shown that sildenafil is selective for PDE5, which is involved in the erection process. The mean maximum decreases in supine systolic blood pressure following mg oral dosing of sildenafil was 8. Sildenafil is not indicated for use by women. Cases of non-arteritic anterior ischaemic optic neuropathy, a rare condition, have been reported spontaneously and in an observational study in connection with the intake of sildenafil and other PDE5 inhibitors see section 4. There was no increase in adverse events with the higher dose. Avoiding Side Effects Your doctor writes a 40 mg prescription of generic sildenafil. Throat tightness, Nasal oedema, Nasal dryness. This site uses cookies. Sildenafil metabolism is dise mediated by the cytochrome P CYP isoforms 3A4 sildenafil route dose 2C9 minor route. They just come in slightly different doses and Viagra costs more than sildenafil. Sign Up Log In Cancel. In order to minimise the potential for developing postural hypotension, patients should be recommended stable on alpha-blocker therapy prior to initiating sildenafil treatment. For the full list of excipients, see section 6. This increase is particularly helpful for dealing with: Name of the medicinal product 2. Concomitant use with alpha-blockers.

Company contact details Pfizer Limited. Urologicals; Drugs used in erectile dysfunction. The most commonly reported adverse reactions in clinical studies among sildenafil treated patients were headache, flushing, dyspepsia, nasal congestion, dizziness, nausea, hot flush, visual disturbance, cyanopsia and vision blurred. Maximum observed plasma concentrations are reached within 30 to minutes median 60 minutes of oral dosing in the fasted state. The film coating of the tablet contains lactose. Chest pain, Fatigue, Feeling hot. Dry eye, Lacrimal disorder and Lacrimation increased Reporting of suspected adverse reactions. Consider protective measures against sexually transmitted diseases. Prior to prescribing sildenafil, physicians should carefully consider whether their patients with certain underlying conditions could be adversely affected by such vasodilatory effects, especially in combination with sexual activity. Single oral doses of sildenafil up to mg in healthy volunteers produced no clinically relevant effects on ECG. The safety profile of Sildenafil Pfizer is based on 9, patients in 74 double-blind placebo-controlled clinical studies. In order for Sildenafil to be effective, sexual stimulation is required. Posology Use in adults The recommended dose is 50 mg taken as needed approximately one hour before sexual activity. There was no increase in adverse events with the higher dose. Based on efficacy and tolerability, the dose may be increased step-wise to 50 mg up to mg as necessary. If Sildenafil is taken with food, the onset of activity may be delayed compared to the fasted state see section 5. In order to minimise the potential of developing postural hypotension in patients receiving alpha-blocker treatment, patients should be stabilised on alpha-blocker therapy prior to initiating sildenafil treatment. Print this page Add to My Med List. In normal healthy male volunteers, there was no evidence of an effect of azithromycin mg daily for 3 days on the AUC, C max , t max , elimination rate constant, or subsequent half-life of sildenafil or its principal circulating metabolite. Caution is advised when sildenafil is administered to patients taking an alpha-blocker, as the co-administration may lead to symptomatic hypotension in a few susceptible individuals see section 4. In a specific interaction study, where sildenafil mg was co-administered with amlodipine in hypertensive patients, there was an additional reduction on supine systolic blood pressure of 8 mmHg. Company contact details Pfizer Limited. Distribution The mean steady state volume of recoommended V d for sildenafil eecommended l, indicating distribution into the tissues. Since sildenafil clearance is reduced in patients with hepatic impairment e. Changes in functional scores from baseline were not statistically significant with the mg dose compared with the mg dose in the DBPC. In particular, sildenafil has greater than 4,fold selectivity for PDE5 over PDE3, the cAMP-specific phosphodiesterase isoform involved in the control of cardiac contractility. Use in adults The recommended dose is og mg taken as needed approximately one hour before sexual activity. Hypromellose Lactose monohydrate Triacetin Titanium dioxide E