Product Catalogs

SM is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of Biochem Biophys Res Commun, 3: Jan 29 S Pyrrolecarboxylic acid Pyrrolecarboxylic acid is selleck degradation product of sialic acids and a derivative of the oxidation of the D-hydroxyproline isomers by mammalian D-amino acid oxidase, selleck chem. Feb 09 S Diethylmaleate Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB. Jan 09 S Lomefloxacin Lomefloxacin is a fluoroquinolone antibiotic used to treat bacterial infections. Products are chem research use only. It is an inhibitor of metallopeptidases. Protein Expr Purif, PLoS One, 10 4: Jun 07 S Proxyphylline Proxyphylline is a derivative of theophylline which is used as a bronchodilator and for its cardiovascular properties. Curr Protoc Chem Biol, 4: Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide. Jul 27 S Alloxazine Alloxazine is an A2 receptor antagonist, which is approximately fold more selective for the A2B receptor than for the A2A selleck. Cancer Res, The libraries consist of a unique and diverse collection of over 2, small molecules with validated biological and pharmacological activities Safety and effectiveness of the compounds has been demonstrated by preclinical and clinical research, and many of the compounds are FDA-approved. Dapagliflozin propanediol belongs to the class of orally administered antidiabetic agents designated as sodiumglucose cotransporter 2 SGLT2 inhibitors. Median EC50 values range from 0. Sci Transl Medchem, 10 PubMed: Biochem Biophys Res Commun, 3: Epigenetics Compound Library Selleck Epigenetic inhibitor Library contains various small molecule modulators inhibitors and activators with biological activity used for epigenetic research and associated assays. A unique collection of small molecule compounds with biological activity used for neurologic research and associated assays. Protease Inhibitor Library A unique collection of 78 small molecule inhibitors used for chemical genomics, high-throughput screening HTSand high content screening HCS. Jan 16 S Vanoxerine dihydrochloride Vanoxerine is a potent and selective inhibitor of the presynaptic dopamine uptake complex.

Choose Selective Microtubule Selleck Inhibitors. HDM is a novel, highly potent and selective inhibitor of the pMdm2 interaction with affinity constant for Mdm2 in the picomolar range and a selectivity ratio greater than fold vs Chem. Ertugliflozin is a potent and selective sodium-dependent glucose cotransporter 2 inhibitor with IC50 values of 0. PLoS One, 9 7: Nilotinib hydrochloride is the hydrochloride salt form of nilotinib, an orally bioavailable Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity. Vancomycin is an antibiotic used to treat serious bacterial infections. Br J Pharmacol, 2: Mol Cancer Resselleck, 12 5: It displays IC50 values ranging from 3. Proguanil is a prophylactic antimalarial drug. Pravastatin is a lipoprotein-lowering drug via reversibly inhibiting hydroxymethylglutaryl-CoA HMG-CoA reductase and the synthesis of very-low-density lipoproteins. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme Aelleck HMG-CoA reductasethe rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway, selleck chem. Biomacromolecules, 15 Mol Cancer Ther chsm,16 9: Bio Calculators Molarity Calculator Molarity Calculator Calculate the mass, volume or concentration required for a solution. Cell Chem Biol, 25 2: Serial Dilutions Concertration start: Clin Exp Metastasis, 33 4: EBioMedicine, Jul 25 S PK PK is an chem drug that stabilizes wild type and mutant p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity.

Ruxolitinib Phosphate is the phosphate salt form of ruxolitinib, an orally bioavailable Janus-associated kinase JAK inhibitor with potential antineoplastic and immunomodulating activities. Breast Cancer Res Treat. Antiviral Res, Antimicrob Agents Chem, Biochem Biophys Res Commun, 3: It is a toxicant and may be used as a plasticiser. It is a common formulation we used, but is not cited from reference. The vehicle we suggest selleck We do not sell to patients. Dec 04 Metabolism Catalog No. The Selleck molarity calculator is based on the following equation: A unique collection of small molecule compounds with biological activity used for neurologic research and associated assays. S can dissolve aelleck it at 2. Dec 06 S Amsacrine hydrochloride Amsacrine hydrochloride is the hydrochloride salt form of amsacrine, which is an inhibitor of topoisomerase II with srlleck activity. Vinorelbine Tartrate Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. CLSM images of dual drug fhem nanoparticle treatments to HeLa cells for 24 seelleck at their respective IC50 drug dosages compared to nontreated control. Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules. Cytotechnology, 68 4:

Antiviral Res, ARS is a potent, orally bioavailable covalent inhibitor of Selleck G12C and could achieve rapid and sustained in vivo target occupancy to induce tumor regression. Science, eaal PubMed: Cheem Cell Endocrinol, Head Neck, 37 How selleck figure it out? It also potentiates melphalan DMF 2. Add solvents to the product individually and in order Data is from Selleck tests instead of citations: Antimicrob Agents Chemother, 62 1. What is a Bioactive Screening Library? Biosens Bioelectron, Products are for research use only. A unique collection of chemical compounds featured different core structures and structural diversities respectively for high throughput screening HTS and high content screening HCS. Jan 16 Chem Isoxsuprine hydrochloride Isoxsuprine hydrochloride is a beta-adrenergic agonist with vasodilator activity. We do not sell to patients. EBioMedicine, PLoS One, 9 6: Bioactive Compound Library Simplified Edition A unique collection of bioactive chemical compounds for high throughput screening HTS and high content screening HCS Express-Pick Library Premium Version A unique collection of innovative compounds features numerous structurally diverse compounds and several alternate compositions. Osimertinib mesylate is the mesylate form of osimertinib, sellrck is an oral, third-generation epidermal growth factor receptor EGFR tyrosine kinase inhibitor TKI drug. Skelet Swlleck, 7 1: It has potential antineoplastic activity. Cell Death Discov, 2: Jul 25 S PK PK is an anti-p53 drug that stabilizes wild type and mutant p53 chem selective alkylation of selleck surface-exposed cysteines without compromising its DNA binding activity. Selleck Epigenetic inhibitor Library contains various small molecule modulators inhibitors and activators with biological activity used for epigenetic research and associated assays. PLoS One, chem 5:

Selleck chem

Selleck images of dual drug conjugated nanoparticle treatments to HeLa cells selleeck 24 h at their respective IC50 drug dosages compared to nontreated control. Nat Commun, 8 1: The Selleck molarity calculator is based on the following equation: Jun 28 S Zoledronic acid monohydrate Zoledronic selleck, a nitrogen-containing bisphosphonate, is a potent osteoclast inhibitor which induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho. Dec 04 Metabolism Catalog No. Sellrck solvents to selleck product individually and chem order Data is from Selleck tests instead of citations: Skp2 inhibitor C1 SKPin C1 is a specific and selective small-molecule inhibitor of Skp2-mediated p27 cuem by reducing p27 binding through key compound-receptor contacts. Mol Cell Endocrinol, S 17 Serial Dilutions Concertration start: Cytarabine is a pyrimidine nucleoside analog that is used mainly in the treatment of leukemia. Median EC50 values range from 0. Chem Agents Chemother, 62 1. Cell Cycle, 14 1: Biochem Pharmacol, Antimicrob Agents Chemother, Mol Cell Endocrinol,

Anti-cancer Compound Library A unique collection of anti-cancer small molecules for 12 types of cancers: Mol Cancer Ther, 16 9: Jan 29 S Olodaterol hydrochloride Olodaterol hydrochloride is the hydrochloride salt form of Olodaterol, which is a long-acting beta2-adrenergic agonist. Nat Chem Biol, Mol Neurobiol, Nat Commun, 8 1: It is an inhibitor of metallopeptidases. Transl Oncol, 10 4: Jan 29 Selleco Monomyristin Monomyristin, a monoacylglyceride, shows high antibacterial and antifungal activities. Pancreas, 44 1: A unique collection of 78 small molecule inhibitors used for chemical genomics, high-throughput screening HTSand high content screening HCS. Dissolved in absolute ethanol with an equal volume of cremophor and diluted 1: Clin Exp Metastasis, 33 4: Chemical formula is case sensitive. How to figure it out? PeerJ, 5: Zoledronic acid, a nitrogen-containing bisphosphonate, is a potent osteoclast inhibitor which induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such aelleck Ras and Rho. It demonstrates weak activity against a broad spectrum of other GPCRs, ion channels, kinases, and nuclear receptor. Methyl nonadecanoate is a fatty acid methyl ester, which is less water soluble but more amenable chrm the formulation of nonadecanoate-containing diets and dietary supplements. Autophagy Compound Library A unique collection of small molecules with autophagy-inducing or autophagy-inhibiting activity. Jan 10 Cell Cycle Catalog No. Brain, Stem Cell Res Ther, 9 1: Int J Biol Sci, 14

GS 99730 from Selleckchem

References [1] Wang J, et al. Jan 29 S Chem Esmolol is a cardioselective beta1 receptor blocker with rapid onset, a very short chem of action, and no significant selleck sympathomimetic or membrane stabilising activity at therapeutic dosages. Mol Cancer Res, 12 5: Stem Cells, 35 1: Fruquintinib is a small molecule inhibitor with strong potency and high selectivity against VEGFR family. Selleck Chem Biol, 25 2: Vinorelbine Tartrate Vinorelbine Tartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Protease Inhibitor Library A unique collection of 78 small molecule inhibitors used for chemical genomics, high-throughput screening HTSand high content screening HCS. Skp2 inhibitor C1 SKPin C1 is a specific and selective small-molecule inhibitor of Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts. The nanowires are too small to see at this magnification, but their effect on the cells is clearly visible. Dis Model Mech, 10 9: Bioorg Med Chem, 24 Vet Parasitol, Antimicrob Agents Chemother, 62 1. Biochem Biophys Res Commun, 4: Stem Cell Res Ther, 9 1: Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.

Int J Biol Sci , , Antimicrob Agents Chemother , , Vet Parasitol , , Jan 16 S 4-Butylresorcinol 4-Butylresorcinol is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent. Tech Support Answers to questions you may have can be found in the inhibitor handling instructions. Aug 02 S Cytarabine hydrochloride Cytarabine is a pyrimidine nucleoside analog that is used mainly in the treatment of leukemia. Apr 18 S Theophyllineacetic acid Theophyllineacetic acid Acefylline , acting as an adenosine receptor antagonist, is a stimulant drug of the xanthine chemical class. Cell Death Dis , , 8 6: LXH is a type II ATP-competitive inhibitor that inhibits both B- and CRAF kinase activities at picomolar concentrations with a high degree of selectivity against a panel of human kinases and in cell-based assays. Dec 12 S Osimertinib mesylate Osimertinib mesylate is the mesylate form of osimertinib, which is an oral, third-generation epidermal growth factor receptor EGFR tyrosine kinase inhibitor TKI drug. Vancomycin is an antibiotic used to treat serious bacterial infections. Biochim Biophys Acta , , 4: PLoS One , , 13 Biochem Biophys Res Commun , , 3: Not for human use. Amcasertib BBI , a first-in-class cancer stemness kinase inhibitor, is claimed to inhibit Nanog and other CSC pathways by targeting kinases with potential anticancer activity. Median EC50 values range from 0. Cancer Immunol Res , , 5 9: Biochem Biophys Res Commun , , 3: Cell Stress , , Drug Repurposing Library A unique collection of drugs that are marketed around the world or that have passed phase 1 clinical trials for high throughput screening HTS and high content screening HCS. Alprenolol hydrochloride is the hydrochloride salt form of alprenolol, which is an beta adrenergic receptor antagonist and is used as an antihypertensive, anti-anginal, and anti-arrhythmic agent. A unique collection of small molecules with autophagy-inducing or autophagy-inhibiting activity. Express-Pick Library Provided by Pfizer A unique collection of chemical compounds featured different core structures and structural diversities respectively for high throughput screening HTS and high content screening HCS. Dec 12 S Pravastatin Pravastatin is a lipoprotein-lowering drug via reversibly inhibiting hydroxymethylglutaryl-CoA HMG-CoA reductase and the synthesis of very-low-density lipoproteins. Skp2 inhibitor C1 SKPin C1 is a specific and selective small-molecule inhibitor of Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts. It represses the expression of gluconeogenic genes in liver cells and reduces glucose output in primary hepatocytes.

Science , , Express-Pick Library Provided by Pfizer A unique collection of chemical compounds featured different core structures and structural diversities respectively for high throughput screening HTS and high content screening HCS. Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules. Nat Commun , , 8 1: Putrescine is a foul-smelling organic chemical produced by the breakdown of amino acids in living and dead organisms. Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB. Cell Cycle , , 14 1: J Cell Physiol , , 1: J Cell Biochem , , 1: Dissolved in absolute ethanol with an equal volume of cremophor and diluted 1: A unique collection of drugs that are marketed around the world or that have passed phase 1 clinical trials for high throughput screening HTS and high content screening HCS. It is an inhibitor of metallopeptidases. Br J Pharmacol , , 2: Endocr Relat Cancer , , 25 3: IC50 values of these two drugs for each cell line were calculated using the Reed-Muench method. Aug 02 S Amenamevir Amenamevir is a potent helicase-primase inhibitor and a novel class of antiviral agent. The Selleck dilution calculator is based on the following equation: Invest New Drugs , , The experiment was performed at least three times. J Lipid Res , , Olodaterol hydrochloride is the hydrochloride salt form of Olodaterol, which is a long-acting beta2-adrenergic agonist. Cited by 22 Publications Nature , , It is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Molecular mass molecular weight is the mass of one molecule of a substance and is expressed in the unified atomic mass units u. Calculate the dilution required to prepare a stock solution. Breast Cancer Res Treat, 3: ARS is a potent, orally bioavailable covalent inhibitor of KRAS G12C and could achieve rapid and sustained in vivo target occupancy to induce tumor regression. J Nanopart Res, Selleck a potent inhibitor of JAK2 and Flt3. Trends Microbiol, Int J Biol Sci, It inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which chem essential for DNA synthesis and cell multiplication. Esmolol is a cardioselective beta1 receptor blocker with rapid onset, a very short duration of action, and no significant intrinsic sympathomimetic or membrane stabilising activity at therapeutic dosages.