PDR Search

Always consult your dosage provider to ensure the information displayed on this page applies to your doaage circumstances. Concurrent use may increase the risk for QT prolongation, staxyn dosage. Staxyn Images. This material is provided for educational purposes only and is not intended for medical advice, diagnosis staxyh treatment. Hearing loss, which may be accompanied sosage tinnitus and dizziness, has been reported in temporal association with the intake of PDE5 inhibitors, including vardenafil; however, it is unknown if the hearing loss is directly related to PDE5 inhibitors or to other factors. Major Although data are limited, staxyn of efavirenz and vardenafil may increase the risk for QT prolongation and torsade de pointes TdP. Vardenafil use is not recommended in these patients until dodage dosage is available. Vardenafil is metabolized by CYP3A4. Elbasvir; Grazoprevir: Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with vardenafil include venlafaxine. Vardenafil is also associated with QT prolongation. Use lapatinib with extreme caution, if at all, in patients taking CYP3A4 substrates that also have potential to staxyn QT prolongation such as vardenafil. Avoid medication errors by using only the form and strength your doctor prescribes. Availability Prescription only. This risk is generally higher at elevated drugs concentrations of phenothiazines. Artemether; Eosage Tolterodine has been associated with dose-dependent prolongation of the QT interval, especially in poor CYP2D6 metabolizers. Major At high doses, loperamide has been associated with serious cardiac toxicities, including syncope, ventricular tachycardia, QT prolongation, torsade de pointes TdPand cardiac arrest. Vardenafil is a substrate of the hepatic isoenzyme CYP3A4; telaprevir inhibits this isoenzyme.

Common side effects of Staxyn include facial flushing, headache, stuffy nose, and upset stomach. Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate: Dronedarone administration is associated with a dose-related increase in the QTc interval. Carbetapentane; Phenylephrine: Severe Concomitant use of dronedarone and vardenafil is contraindicated. Vardenafil orally disintegrating tablets ODT provide increased exposure as compared to the regular tablets; therefore, use with potent CYP3A4 inhibitors such as delavirdine is not recommended. Major Pentamidine has been associated with QT prolongation. Moderate The hypotensive effects of nitroprusside may be augmented by phosphodiesterase inhibitors. Further, use vardenafil with caution in patients with cardiac disease or other conditions that may increase the risk of QT prolongation including cardiac arrhythmias, heart failure, bradycardia, myocardial infarction, hypertension, coronary artery disease, hypomagnesemia, hypokalemia, hypocalcemia, or in patients receiving medications known to prolong the QT interval or cause electrolyte imbalances. Generic Name: Staxyn is taken only when needed, about 60 minutes before sexual activity. Your doctor may lower your dose or raise your dose, depending on how your body reacts to this medication. Major Coadministration of vardenafil with fosamprenavir, especially when 'boosted' with ritonavir, is expected to substantially increase vardenafil plasma concentrations and may result in increased associated adverse events including hypotension, syncope, visual changes, and prolonged erection. Health care professionals should consider whether the individual would be adversely affected by vasodilatory events. Droperidol administration is associated with an established risk for QT prolongation and torsades de pointes TdP. Staxyn is only for use in men. Staxyn orally disintegrating tablets should not be used in place of Levitra vardenafil regular tablets. A cardiovascular examination, including an ECG, should be obtained in all patients prior to initiating anagrelide therapy. Use in Special Populations Hepatic Impairment:

Further information

Ibutilide administration can cause QT prolongation and torsades de pointes TdP ; proarrhythmic events staxyn be anticipated. In rare instances, men taking PDE5 inhibitors oral erectile dysfunction medicines, including Staxyn, reported a sudden decrease or loss of vision in one or both eyes. Vorinostat therapy is associated with a risk of QT prolongation. Concurrent use may also result in increased toxicity or decreased efficacy of vardenafil. Priapism must be dosage as soon as possible or lasting damage can happen to your penis including the inability to have erections. Delavirdine is expected to substantially increase vardenafil plasma concentrations and may result in vardenafil-related adverse events including hypotension, visual changes, and priapism. Vardenafil orally disintegrating tablets provide increased exposure as compared to the regular tablets; therefore, the orally disintegrating tablets should not be used in patients with moderate or severe hepatic disease Child-Pugh class B or Dosagd or in patients on hemodialysis. Erythromycin is generally considered by experts to have an established risk for QT prolongation cosage torsades de pointes TdP. Cyclic guanosine monophosphate causes smooth muscle relaxation in the corpus cavernosum thereby allowing inflow of blood; the exact mechanism by which cGMP stimulates relaxation of smooth muscles has not been determined. Advise patients to stop use of all phosphodiesterase 5 PDE5 inhibitors, including vardanafil, and seek medical attention for evaluation in the event of a sudden visual disturbance in 1 or both eyes. Ondansetron has been associated doeage a dose-related increase in the QT staxgn and postmarketing reports of TdP. Swallow several times as the tablet dissolves. Patients with mild hepatic impairment Child-Pugh class A: Common side effects of Staxyn include facial flushing, headache, stuffy nose, staxyn dosage, and upset stomach. Major Avoid coadministration of hydroxychloroquine and vardenafil. Because of the potential for torsade de pointes TdPuse of cisapride with vardenafil is contraindicated. The combination of sapropterin and a phosphodiesterase PDE5 inhibitor did not significantly dosage blood pressure when administered concomitantly in animal studies. If used together, the vardenafil dose should not exceed 2. Gemifloxacin may also prolong the QT interval in some patients, with the maximal change in the QTc interval occurring approximately 5 to 10 hours following oral administration. It is recommended not to exceed a single 5-mg dose of vardenafil in a hour period when used in combination with moderate CYP3A4 inhibitors, such as grapefruit juice.

By clicking Subscribe, I agree to the Drugs. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with vardenafil include propafenone. Carbinoxamine; Phenylephrine: Dosage is specifically associated with an established risk of QT prolongation and TdP; case reports have included patients receiving therapeutic doses of chlorpromazine. Vardenafil, at therapeutic 10 mg and supratherapeutic 80 mg doses, produces an increase in QTc interval e. Erythromycin; Sulfisoxazole: Tell your doctor if you are pregnant or plan to become pregnant. The concomitant use of certain potent hepatic cytochrome P 3A4 inhibitors may result in a requirement to adjust the vardenafil dosage see Dosage and Drug Interactions. Choose one. If vardenafil dose adjustments are made, re-adjust the dose upon completion dosage telaprevir treatment. Phosphodiesterase type 5 is also abundant in lung tissue and esophageal smooth muscle. Additionally, erythromycin inhibits CYP3A4. The vardenafil staxyn disintegrating tablets provide increased exposure as compared to the regular tablets; therefore, do staxyn use the orally disintegrating tablets with moderate or potent CYP3A4 inhibitors, staxyn dosage, such as atazanavir. Nitrates can also be found in other medicines such as isosorbide dinitrate or isosorbide mononitrate. Vardenafil is a substrate of the hepatic isoenzyme CYP3A4; boceprevir inhibits this isoenzyme.

Staxyn dosage

Buprenorphine has been associated with QT prolongation and has a possible risk of torsade de pointes Staxyn. Major Avoid coadministration dosage encorafenib dosage vardenafil due to the potential for additive QT prolongation. How was your experience with Staxyn? These reports generally involved patients with concurrent medical conditions or concomitant medications that may have been contributory. Staxyn Drug Class Back to Top. The vardenafil orally disintegrating tablets provide increased exposure as compared to the regular tablets; therefore, do not use the orally disintegrating tablets with moderate or potent CYP3A4 inhibitors, such as clarithromycin Amoxicillin; Clarithromycin; Omeprazole: Subscribe to free Drugs. If the use of nilotinib and vardenafil cannot be avoided, a vardenafil dose reduction may be necessary; close monitoring of the QT interval is recommended. Alfuzosin has also been reported to cause QT prolongation; use together may increase this risk. Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Not all possible drug interactions are listed here, staxyn dosage. Arrhythmias, sinus bradycardia, and conduction disturbances have occurred during octreotide therapy warranting more cautious monitoring during octreotide administration in higher risk patients with cardiac disease. Drugs with a possible risk for QT prolongation and TdP that staxyn be used cautiously and with close monitoring with metronidazole include vardenafil. Major If possible, drugs that are known to prolong the QT interval should be discontinued prior to initiating arsenic trioxide therapy. In addition, there are postmarketing reports of torsade de pointes. The vardenafil orally disintegrating tablets contain aspartame, which is a source of phenylalanine. Use leuprolide and vardenafil together with caution and with close clinical monitoring if use together is not avoidable.

Severe Pimozide is associated with a well-established risk of QT prolongation and torsade staxyn pointes TdP. It can be expected that concomitant administration of bosentan, a CYP3A4 enzyme-inducer, will decrease plasma levels of vardenafil, however, no interaction studies have been performed. How likely would you be to recommend Staxyn to doasge friend? Generic Back to Top. Other potent CYP3A4 inhibitors such as, imatinib, STI, would be expected to have effects doage vardenafil clearance when coadministered. Vardenafil is extensively distributed throughout the body. Required field. Monitor patients for efficacy. Ribociclib is a strong CYP3A4 inhibitor that has been shown to prolong the Staxyn interval in a concentration-dependent manner. Both therapeutic and supratherapeutic doses of vardenafil produce an increase in QTc interval e. Patients should be stable on dosage therapy before starting PDE5 inhibitor therapy. In addition, coadministration of vardenafil, a CYP3A4 substrate, with fluvoxamine, a moderate CYP3A4 inhibitor, may substantially increase vardenafil plasma concentrations and result in vardenafil-related adverse events including hypotension, visual changes, and priapism. Lower doses ddosage vardenafil film-coated tablets should be used as initial dosage in these patients. We comply with the HONcode standard for trustworthy health information - verify here. If these drugs are given together, dosage monitor for prolongation of the QT interval. Major Tacrolimus causes QT prolongation. Further, use vardenafil with caution in patients with cardiac disease or other conditions that may increase the risk of QT prolongation including cardiac arrhythmias, heart failure, bradycardia, myocardial infarction, hypertension, coronary artery disease, hypomagnesemia, hypokalemia, hypocalcemia, or in patients receiving medications known to prolong the QT interval or cause electrolyte imbalances, staxyn dosage. Staxyn, INH; Rifampin: What tips would you provide a friend before taking Staxyn?

Advise patients to stop use of all phosphodiesterase 5 PDE5 inhibitors, including vardanafil, and seek medical attention for evaluation in the event of a sudden visual disturbance in 1 or both eyes. Side effects in more detail. Arrhythmias, sinus bradycardia, and conduction disturbances have occurred during octreotide therapy warranting more cautious monitoring during octreotide administration in higher risk patients with cardiac disease. Major There may be an increased risk stxyn QT prolongation and torsade de pointes TdP during concurrent use of mirtazapine and vardenafil. Drugs with a possible risk for QT prolongation that should be used cautiously with vardenafil include the beta agonists. Clarithromycin is also a known staxyn of the hepatic cytochrome isozyme Dosage. These effects may be beneficial in certain staxyn disorders involving dosagd esophagus such as diffuse spasm, nutcracker esophagus, and hypertensive LES. Fosaprepitant etaxyn IV as a single dose staxyn the AUC of midazolam given on days 1 and 4 by approximately 1. Guanylate Cyclase GC Stimulators, such as riociguat: Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with vardenafil include clozapine. In particular, caution should be used if vardenafil is prescribed in the following patient groups: Ondansetron has been associated with a dose-related increase in the QT interval and postmarketing reports of TdP. Use of these drugs together may increase the risk of developing torsade de pointes-type ventricular dosage. Daily news summary. Available for Android and iOS devices. A course of an alternate PDE5 inhibitor may be considered if a patient does not respond to a PDE5 inhibitor trial; a treatment failure may be deemed after at least 4 unsuccessful trials. Moderate Due to increased vardenafil exposure, do not use vardenafil orally disintegrating tablets with duvelisib; do not exceed a single dose of 5 mg per hour period of dosage oral tablets. Lopinavir; Ritonavir: Vorinostat should be used with caution if given with vardenafil. Dyspepsia is one of the more common adverse reactions associated with PDE inhibitor therapy.

Common Staxyn Side Effects

Torsade de pointes TdP and complete atrioventricular block have been reported. Halogenated Anesthetics: In addition, haloperidol is a substrate staxyyn CYP2D6. Lopinavir; Ritonavir: Back to top. Follow the directions on your prescription label carefully. A minority of patients staxyn the inherited condition retinitis pigmentosa have genetic disorders of retinal phosphodiesterases. No dose adjustment is required. Major Due to the potential for QT prolongation and torsade de pointes TdPcaution is advised when administering tolterodine with vardenafil. Vardenafil is well-adsorbed from the gastrointestinal staxyn. Drugs with a possible risk for QT prolongation dosae TdP that should be used cautiously with vardenafil include ezogabine. Major Due to the potential for QT prolongation and torsade de pointes TdPdosage is advised when administering telavancin with vardenafil. Last updated on Dec 11, Atazanavir; Cobicistat: The clinical relevance of the in vivo effect of encorafenib on CYP3A4 is not established. Do not use. Staxyn may contain phenylalanine. Do not use Staxyn dosage you are using these drugs. Additionally, post-marketing surveillance for ofloxacin has identified very rare cases of TdP.

Place the tablet in your mouth and allow it to dissolve without chewing. If possible, avoid coadministration. There is no known indication for the use of vardenafil in neonates, infants, or children. Darunavir; Cobicistat: Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with vardenafil include degarelix. Additionally, fluconazole has been associated with prolongation of the QT interval; do not use with other drugs that may prolong the QT interval and are metabolized through CYP3A4, such as vardenafil. Related Drug Information Drug Summary. Moderate Sparfloxacin is associated with an established risk for QT prolongation and torsades de pointes. No dose adjustments are required when treating erectile dysfunction. Clarithromycin is also a known inhibitor of the hepatic cytochrome isozyme CYP3A4. Coadministration may increase the risk for QT prolongation. Levomethadyl is contraindicated in combination with other agents that may prolong the QT interval. You could be having a serious side effect. Adult males taking ritonavir. Any drug known to have potential to prolong the QT interval should not be coadministered with droperidol. An interruption of vandetanib therapy or dose reduction may be necessary for QT prolongation. Major Concurrent use of vardenafil and levofloxacin should be avoided due to an increased risk for QT prolongation and torsade de pointes TdP. Phosphodiesterase inhibitors have vasodilatory properties, and nitroprusside is a potent vasodilator. Major Paliperidone has been associated with QT prolongation; torsade de pointes TdP and ventricular fibrillation have been reported in the setting of overdose. Do not administer with any liquids. Especially tell your doctor if you take any of the following:. Major Avoid coadministration of glasdegib with vardenafil due to the potential for additive QT prolongation. Patients taking moderate CYP3A4 inhibitors, such as verapamil, may need to have their vardenafil dose decreased to 5 mg PO in a hour period. Severe Coadministration of riociguat and vardenafil is contraindicated due to the risk of hypotension. It is not clear whether vardenafil is the actual cause of vision loss.

staxyn dosage

Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with vardenafil include olanzapine. Torsade de pointes TdP and complete atrioventricular block have been reported. You should not use Staxyn if you are allergic to vardenafil, or if you take other medicines to treat pulmonary arterial hypertension , such as riociguat Adempas. Arsenic Trioxide: Nitrates can also be found in other medicines such as isosorbide dinitrate or isosorbide mononitrate. Adult males taking ritonavir. Patients refractory to PDE5 inhibitors should be counseled on appropriate use, potentially modifiable factors e. Daily news summary. In addition, efavirenz induces CYP3A4 and may decrease serum concentrations of drugs metabolized by this enzyme, such as vardenafil. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with vardenafil include mefloquine. For norfloxacin specifically, extremely rare cases of TdP were reported during post-marketing surveillance. Ask your doctor or pharmacist for more information. Angina is a symptom of heart disease and can cause pain in your chest, jaw, or down your arm. Priapism must be treated as soon as possible or lasting damage can happen to your penis including the inability to have erections. Use Staxyn orally disintegrating tablets exactly as prescribed by your doctor. According to the manufacturer, use of quetiapine should be avoided in combination with drugs known to increase the QT interval. In addition, phosphodiesterase type-5 PDE5 is found in platelets, and PDE5 inhibitors may potentiate the nitric oxide-mediated platelet anti-aggregatory activity of nitroprusside. Required field. Alcoholism, angina, aortic stenosis, bradycardia, cardiac arrhythmias, cardiac disease, coronary artery disease, diabetes mellitus, females, heart failure, hypertension, hypocalcemia, hypokalemia, hypomagnesemia, hypotension, idiopathic hypertrophic subaortic stenosis, long QT syndrome, malnutrition, myocardial infarction, QT prolongation, stroke, thyroid disease. Vardenafil has a greater selectivity for PDE5 versus PDE6, an enzyme found in the retina and involved in phototransduction. Major Halogenated anesthetics should be used cautiously and with close monitoring with vardenafil.

Do not take Staxyn if you: Other brands: Tamoxifen has been reported to prolong the QT interval, usually in overdose or when used in high doses. During coadministration, use vardenafil at reduced doses of no more than 2. The elimination half-life of vardenafil and M1 is about 4—5 hours with the use of the film-coated tablets. In addition, phosphodiesterase type-5 PDE5 is found in platelets, and PDE5 inhibitors may potentiate the nitric oxide-mediated platelet anti-aggregatory activity of nitroprusside. Doses should be taken at least 24 hours apart. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with vardenafil include propafenone. Major Concurrent use of tipranavir boosted with ritonavir and varadenafil is expected to substantially increase vardenafil plasma concentrations and may result in increased adverse events including hypotension, syncope, visual changes, and prolonged erection. Inhibitors of CYP3A4 can reduce vardenafil clearance. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with vardenafil include perphenazine. Minor Vardenafil is metabolized by cytochrome P 3A4. Buprenorphine; Naloxone: Major Therapeutic 10 mg and supratherapeutic 80 mg doses of vardenafil produces an increase in QTc interval e. Sotalol administration is associated with QT prolongation and torsades de pointes TdP. Gastroesophageal reflux disease GERD , hiatal hernia. Both therapeutic and supratherapeutic doses of vardenafil produced an increase in QTc interval e. Subscribe to free Drugs. If coadministration cannot be avoided, monitor patients for increased risk of QT prolongation with increased frequency of ECG monitoring. Patients should be stabilized on their alpha blocker therapy prior to starting either avanafil, tadalafil or vardenafil, or if already receiving an optimum dose of these PDE5 inhibitors, the alpha blocker therapy should be started at the lowest possible dose. Vardenafil is a substrate of the stxxyn isoenzyme CYP3A4; telaprevir inhibits this isoenzyme. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with citalopram include vardenafil. Vardenafil is staxyn sensitive CYP3A4 substrate that is associated with QT prolongation at both therapeutic and supratherapeutic doses. Rare case reports stzxyn QT prolongation have been described when dosage is used at lower doses. These effects may be beneficial in certain motor disorders involving the esophagus such as diffuse spasm, nutcracker esophagus, and hypertensive LES. The vardenafil orally disintegrating tablets provide increased dosage as compared to the regular tablets; therefore, do not use the orally disintegrating tablets with moderate or potent CYP3A4 inhibitors, such as saquinavir. Priapism must be treated as soon as possible or lasting damage can happen to your penis including the inability to have erections. It is not possible to determine wtaxyn these events are related directly to these medicines, to other factors such as high blood pressure or diabetes, staxyn dosage, or to syaxyn combination of these. Ask your doctor if it is safe for staxyn to have sexual activity.